何玉萍，博士，副教授

通信地址：上海市宝山区上大路99号

邮箱：yuping_he@shu.edu.cn

研究领域：

不对称催化；手性小分子药物合成新技术；活性天然产物构建

教育经历：

2005/9-2009/6: 安徽师范大学 本科 (导师：杨高升教授)

2009/9-2014/6：中国科学技术大学 博士 (导师：龚流柱教授)

工作经历：

2014/7-2015/7：山东理工大学 讲师

2017/10-2021/4: 瑞士洛桑联邦理工学院 (EPFL) 博士后 (导师：Jieping Zhu 教授)

2021/9-2024/4：上海交通大学药学院 博士后

2024/4-至今：8455新葡萄场网站 副教授

代表性科研项目：

上海市海外高层次人才引进项目

中国博士后面上基金一等资助

代表性论文著作：

1. Rui Quan, Xing-Zi Li, Zi-Qi Wang, Yu-Ping He,* Hua Wu*, Catalytic Asymmetric Cyclizative Rearrangement of Anilines and Vicinal Diketones to Access 2,2-Disubstituted Indolin-3-ones, Adv. Sci. 2024, 2402532.

2. Xing-Zi Li, Yu-Ping He, Hua Wu*, Multicomponent Cyclizative 1,2-Rearrangement Enabled Enantioselective Construction of 2,2-Disubstituted Pyrrolinones, Angew. Chem. Int. Ed., 2024, 63, e202317182.

3. Di Tian, Zhuo-Chen Li, Ze-Hua Sun, Yu-Ping He, Li-Ping Xu,* Hua Wu*, Catalytic Enantioselective Biltz Synthesis, Angew. Chem. Int. Ed., 2023, 62, e202313797.

4. Xing-Zi Li, Yu-Ping He, Hua Wu*, Zinc chloride-catalyzed cyclizative 1,2-rearrangement enables facile access to morpholinones bearing aza-quaternary carbons, Commun. Chem. 2023. 6, 216.

5. Yu-Ping He, Di Tian, Xing-Zi Li, Hua Wu*, Recent Advances in Asymmetric Catalytic Construction of Oxa-Quaternary Carbon Centers, Org. Chem. Front., 2023, 10, 3110-3129. (Invited review)

6. Yu-Ping He,# Rui Quan,# Xing-Zi Li, Jieping Zhu, Hua Wu*, Angew. Chem. Int. Ed., 2023, e202217954. (Very Important Paper)

7. Yu-Ping He,# Hua Wu,# Qian Wang and Jieping Zhu*, Catalytic Enantioselective Synthesis of Morpholinones Enabled by Aza-Benzilic Ester Rearrangement, J. Am. Chem. Soc., 2021, 143, 7320.

8. Yu-Ping He,# Jian Cao,# Hua Wu, Qian Wang and Jieping Zhu*, Catalytic Enantioselective Aminopalladation-Heck Cascade, Angew. Chem. Int. Ed., 2021, 60, 7093.

9. Yu-Ping He,# Hua Wu,# Qian Wang and Jieping Zhu*, Palladium-Catalyzed Enantioselective Cacchi Reaction: Asymmetric Synthesis of Axially Chiral 2,3-Disubstituted Indoles, Angew. Chem. Int. Ed., 2020, 59, 2105. (Hot paper).

10. Hua Wu*, Yu-Ping He, Feng Shi*, Recent Advances in Chiral Phosphoric Acid Catalyzed Asymmetric Reactions for the Synthesis of Enantiopure Indole Derivatives, Synthesis. 2015, 47, 1990. (Invited review)

11. Hua Wu, Yu-Ping He, and Liu-Zhu Gong*, Cooperation of Transition Metals and Chiral Brønsted Acids in Asymmetric Catalysis. In Cooperative Catalysis; Wiley−VCH, 2015, pp 171−196. (Book chapter)

12. Yu-Ping He, Hua Wu, Liu-Zhu Gong*, Highly enantioselective oxidative tandem cyclization reaction: a chiral ligand and an anion cooperatively control stereoselectivity, Org. Chem. Front., 2014, 1, 473.

13. Hua Wu, Yu-Ping He, Lue Xu, Dong-Yang Zhang, and Liu-Zhu Gong*, Asymmetric Organocatalytic Direct C(sp2)-H/C(sp3)-H Oxidative Cross-Coupling by Chiral Iodine Reagents, Angew. Chem. Int. Ed., 2014, 53,3466.

14. Hua Wu, Yu-Ping He, and Liu-Zhu Gong*, Direct Access to Enantioenriched Spiroacetals through Asymmetric Relay Catalytic Three-Component Reaction, Org. Lett., 2013, 15, 460.

15. Yu-Ping He, H. Wu, Liu-Zhu Gong*, Cascade Hydroamination/Redox Reaction for the Synthesis of Cyclic Aminals Catalyzed by a Combined Gold Complex and Brønsted Acid, Chem. Eur. J., 2013, 19, 5232.

16. Hua Wu, Yu-Ping He, and Liu-Zhu Gong*, The Combination of Relay and Cooperative Catalysis with a Gold/Palladium/Brønsted Acid Ternary System for the Cascade Hydroamination/Allylic Alkylation Reaction, Adv. Synth. & Catal., 2012, 354, 975.

17. Dian-Feng Chen, Zhi-Yong Han, Yu-Ping He, Jie Yu, Liu-Zhu Gong*, Metal-Free Oxidation/C(sp3)-H Functionalization of Unactivated Alkynes Using Pyridine-N-Oxide as the External Oxidant, Angew. Chem. Int. Ed., 2012, 51, 1230

18. Yu-Ping He, Yu-Liu Du, Shi-Wei Luo, Liu-Zhu Gong*, Asymmetric sp3 C-H functionalization via a chiral Bronsted acid-catalyzed redox reaction for the synthesis of cyclic aminals, Tetrahedron Letters, 2011, 52, 706.