报告题目：Utilization of CO2 as a C1 Building Block in Organic Synthesis (二氧化碳作为C1砌块在有机合成中的应用)
报 告 人：Yoshihiro Sato 教授(日本北海道大学)
报告时间：2017年11月21日（周二）15:00
报告地点：校本部HA102
邀请人：许斌 教授
邀请单位：8455新葡萄场网站化学系
报告摘要：Carbon dioxide (CO2) is attractive to synthetic organic chemists as an abundant, cheap, and non-toxic carbon source, and the utilization of CO2 as a C1 buliding blocks in synthetic organic chemistry should bring us a great advantage, especially for realizing the environmentally benign processes. However, CO2 is very stable chemical substances, and how we can bring out the reactivity of CO2 is important. CO2 has mainly two reactivities; one is electrophilicity of the center carbon of CO2, and the other is that C=O double bond can be activated by transition metal complexes. With respect to the former reactivity, we recently developed the synthesis of ?-amino acids by the reaction of ?-amino metal species, prepared from ?-amino sulfone and bimetallic reagent such as TMS-SnBu31 or pinB-SiMe2Ph2, with CO2. More recently, we reported the transition metal-catalyzed carboxylation of nucleophilic ?-ally metal species using CO2.3,4 With respect to the latter reactivity, we developed the synthesis of a chiral ?-amino acids5 or ?-aryloxy carboxylic acids6 through combination of nickel-catalyzed carboxylation of ynamides or aryl ynol ethers and rhodium-catalyzed asymmetric hydrogenation of the resultant carboxylated product. In this lecture, these reactions and the current results will be discussed.
