报告题目： Amino Acid-based Bifunctional Phosphines for Enantioselective Catalytic Reaction（基于氨基酸骨架的双官能团化有机膦催化剂的设计及应用）
报告人：卢一新 教授（新加坡国立大学）
报告时间: 2016年6月3日15:00
报告地点：校本部HA楼102室
邀请人：吴小余 教授
报告人简介：Yixin Lu (卢一新)studied chemistry and received his B.Sc. from Fudan University, Shanghai, and continued his graduate studies in Canada and obtained his Ph.D. in Organic Chemistry under the supervision of the late Prof. George Just from McGill University in 2000. After a short postdoctoral stay with Prof. Peter W. Schiller at Clinical Research Institute of Montreal, Canada, and he then joined Prof Ryoji Noyori’s group in Nagoya University as an RCMS. He started his independent career at the National University of Singapore (NUS) in September, 2003, and he is now a Professor and Deputy Head of Department of Chemistry, NUS. He was a recipient of the Asian Core Program (ACP) Lectureship awards to Japan, China, Chinese Taibei, and Korea from 2009-2014, and he won Young Scientist Award & Outstanding Scientist Award from the Faculty of Science, NUS in 2009 and 2013, respectively. In March 2013, he received GSK-SNIC Award in Organic Chemistry, and he was awarded the Dean’s Chair Professorship in July 2013. His research is focused on synthetic organic chemistry and medicinal chemistry. One of the key areas is asymmetric synthesis and catalysis, and he is particularly interested in developingamino acid-derived organic catalysts for enantioselective reactions.
报告摘要：This talk will be focused on our adventures in asymmetric nucleophilic phosphine catalysis. Recently, we disclosed a series of bifunctional phosphines based amino acid structural motifs (Figure 1). Our phosphine catalysts can be readily prepared, and their structures are highly tunable. Moreover, such phosphine catalysts possess excellent stability, and can be used directly for reactions withoutinert gas protection. Up to date, we have successfully applied our phosphine catalysts to enantioselectiveaza-Morita-Baylis-Hillman (MBH)& MBH reactions, a range of[3+2] cycloadditions, different [4+2] cycloadditions, [4+1] annulation, allylic alkylations, Michael addition, and g-addition reactions. The details of our investigations will be presented, and some mechanistic understandings will also be discussed.
